• Document: Doctoral Thesis. Modulation of Spinal Neural Circuits Induced by Corticospinal. Descending and Peripheral Afferent Inputs
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Doctoral Thesis Modulation of Spinal Neural Circuits Induced by Corticospinal Descending and Peripheral Afferent Inputs Shinji Kubota Division of Integrated Arts and Sciences Graduate School of Integrated Arts and Sciences Hiroshima University September 2016 This thesis consists of four studies concerning activity-dependent spinal cord neuroplasticity. This work was carried out while the author was a doctoral student of the Graduate School of Integrated Arts and Sciences at Hiroshima University, Japan from April 2012 to September 2016. Shinji Kubota September 2016 CONTENTS CHAPTER 1 GENERAL INTRODUCTION ································································1 1.1 Spinal neural circuits ········································································3 1.2 Hoffmann reflex ·············································································9 1.3 Transcranial magnetic stimulation ····················································· 14 1.4 Summary of the aim of the thesis ······················································· 21 CHAPTER 2 EFFECTS OF CORTICOSPINAL DESCENDING INPUTS ON THE ACTIVITY OF RECIPROCAL IA INHIBITION 2.1 Introduction ··············································································· 24 2.2 Methods 2.2.1 Subjects ················································································ 25 2.2.2 Electromyography recording ······················································· 25 2.2.3 H-reflex ················································································ 26 2.2.4 Conditioning stimulation ··························································· 28 2.2.5 Study design ·········································································· 30 2.2.6 Data analysis ········································································· 32 2.3 Results ························································································ 32 2.4 Discussion ···················································································· 36 2.5 Conclusion ··················································································· 38 CHAPTER 3 THE MECHANISMS OF CHANGES IN THE IA PRESYNAPTIC INHIBITION FOLLOWING SKILLED MOTOR TASK 3.1 Introduction ················································································· 40 3.2 Methods 3.2.1 Subjects ················································································ 41 3.2.2 Electromyography recording ······················································· 41 3.2.3 Presynaptic inhibition ······························································· 43 3.2.4 Transcranial magnetic stimulation ················································ 44 3.2.5 Visuomotor task ······································································ 45 3.2.6 Experimental procedures ··························································· 48 3.2.7 Statistical analysis ··································································· 48 3.3 Results ··················

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